Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.53 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.53 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | BRD1 | O95696 | 1/20 | 0.53 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.53 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.53 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982624 | 0.83 | ALDH1A1 (0.51) | SMN1; SMN2LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL5335572 | 0.82 | MAPT (0.57) | SMN1; SMN2LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL9676236 | 0.80 | NPC1 (0.51) | SMN1; SMN2LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL28842217 | 0.79 | NPC1 (0.54) | SMN1; SMN2LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL6985862 | 0.78 | ALDH1A1 (0.78) | SMN1; SMN2LMNAALDH1A1NPC1AGTR1 | |
| SCHEMBL2614387 | 0.78 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAALDH1A1BRD4BRD1 | |
| SCHEMBL17682474 | 0.77 | TSHR (0.70) | SMN1; SMN2LMNAALDH1A1TSHRHPGD | |
| SCHEMBL5343689 | 0.77 | HSD11B1 (0.60) | SMN1; SMN2LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL14629169 | 0.76 | LMNA (0.71) | SMN1; SMN2LMNAALDH1A1BRD4BRD1 | |
| SCHEMBL10939039 | 0.75 | KDM1A (0.70) | LMNAALDH1A1NPC1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991624-B1 | PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-11-19 | — | — | EP | disclosed |
| US-6300342-B1 | FOR THERAPY OR INHIBITING THROMBUS FORMATION; FOR THERAPY OF FIBRIN-DEPENDENT INFLAMMATORY CONDITION | BOEHRINGER INGELHEIM PHARM KG (DE) | 2001-10-09 | — | — | US | disclosed |