Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.78 |
| ▸ | LMNA | P02545 | 4/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.78 |
| ▸ | NAMPT | P43490 | 2/20 | 0.61 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.58 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALPL | P05186 | 1/20 | 0.56 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.55 |
| ▸ | SLC40A1 | Q9NP59 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | G6PD | P11413 | 1/20 | 0.54 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.54 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.54 |
| ▸ | METAP2 | P50579 | 1/20 | 0.54 |
| ▸ | METAP1 | P53582 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979083 | 0.89 | SMN1; SMN2 (0.74) | ALDH1A1LMNASMN1; SMN2NAMPTPFKFB3 | |
| SCHEMBL6986051 | 0.88 | LMNA (0.65) | ALDH1A1LMNASMN1; SMN2KDM4ESLC40A1 | |
| SCHEMBL6981076 | 0.87 | ALDH1A1 (0.76) | ALDH1A1LMNASMN1; SMN2KDM4EALPL | |
| SCHEMBL6978003 | 0.87 | ALDH1A1 (0.76) | ALDH1A1LMNASMN1; SMN2NAMPTPFKFB3 | |
| SCHEMBL6982196 | 0.87 | ALDH1A1 (0.76) | ALDH1A1LMNASMN1; SMN2NAMPTPFKFB3 | |
| SCHEMBL6978649 | 0.87 | ALDH1A1 (1.00) | ALDH1A1LMNASMN1; SMN2NAMPTKDM4E | |
| SCHEMBL6980375 | 0.85 | LMNA (0.65) | ALDH1A1LMNASMN1; SMN2PFKFB3SLC40A1 | |
| SCHEMBL6980648 | 0.85 | LMNA (0.65) | ALDH1A1LMNASMN1; SMN2NAMPTPFKFB3 | |
| SCHEMBL1792342 | 0.85 | MAPT (0.60) | ALDH1A1LMNASMN1; SMN2NAMPTKDM4E | |
| SCHEMBL2055421 | 0.85 | ALDH1A1 (0.68) | ALDH1A1LMNASMN1; SMN2NAMPTPFKFB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991624-B1 | PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-11-19 | — | — | EP | disclosed |
| US-6300342-B1 | FOR THERAPY OR INHIBITING THROMBUS FORMATION; FOR THERAPY OF FIBRIN-DEPENDENT INFLAMMATORY CONDITION | BOEHRINGER INGELHEIM PHARM KG (DE) | 2001-10-09 | — | — | US | disclosed |
| EP-0991624-A1 | PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT | Boehringer Ingelheim Pharma KG (DE) | 2000-04-12 | — | — | EP | disclosed |
| WO-1999000371-A1 | PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-01-07 | — | — | WO | disclosed |