Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | CTSG | P08311 | 1/20 | 0.37 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.37 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6988954 | 0.87 | ALDH1A1 (0.41) | CTSSCTSKITGA4ITGB7ALDH1A1 | |
| SCHEMBL6981171 | 0.86 | CTSS (0.40) | CTSSCTSKITGA4ITGB7SMN1; SMN2 | |
| SCHEMBL6985905 | 0.81 | CTSS (0.36) | CTSSCTSKITGA4ITGB7SMN1; SMN2 | |
| SCHEMBL6942001 | 0.77 | CTSK (0.34) | CTSSCTSKALDH1A1KMT2AMEN1 | |
| SCHEMBL28494073 | 0.76 | CTSS (0.45) | CTSSCTSKITGA4ITGB7SMN1; SMN2 | |
| SCHEMBL6659518 | 0.76 | MMP3 (0.45) | CTSSCTSKKMT2AMEN1HPGD | |
| SCHEMBL6943287 | 0.76 | MMP3 (0.45) | CTSSCTSKKMT2AMEN1HPGD | |
| SCHEMBL6943292 | 0.76 | MMP3 (0.45) | CTSSCTSKKMT2AMEN1HPGD | |
| SCHEMBL6659520 | 0.76 | MMP3 (0.45) | CTSSCTSKKMT2AMEN1HPGD | |
| SCHEMBL6987281 | 0.76 | MMP3 (0.45) | CTSSCTSKKMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |