Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HTR1A | P08908 | 4/20 | 0.52 |
| ▸ | HTR7 | P34969 | 4/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5842200 | 0.99 | NPSR1 (0.58) | NPSR1L3MBTL1ALDH1A1HTR1AHTR7 | |
| SCHEMBL6985422 | 0.83 | SHMT2 (0.64) | NPSR1L3MBTL1ALDH1A1SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL5840743 | 0.83 | SHMT2 (0.63) | NPSR1L3MBTL1ALDH1A1HTR1AHTR7 | |
| SCHEMBL6986827 | 0.83 | SIGMAR1 (0.47) | — | |
| SCHEMBL6986043 | 0.82 | SHMT2 (0.50) | NPSR1L3MBTL1ALDH1A1THRBSMN1; SMN2 | |
| SCHEMBL6978967 | 0.82 | LMNA (0.53) | ALDH1A1CYP2C19LMNAKMT2A | |
| SCHEMBL6980711 | 0.82 | MAPT (0.57) | L3MBTL1ALDH1A1SMN1; SMN2MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL5842696 | 0.82 | CHRM2 (0.49) | — | |
| Hydrochloric Acid SCHEMBL5843596 | 0.82 | SHMT2 (0.49) | L3MBTL1ALDH1A1HTR1AHTR7THRB | |
| Hydrochloric Acid SCHEMBL5842876 | 0.81 | KMT2A (0.55) | ALDH1A1TSHRMEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |