Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | GSK3A | P49840 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6991619 | 0.82 | TYK2 (0.37) | TYK2PDE4DMAPT | |
| SCHEMBL6988688 | 0.81 | ABCC9 (0.41) | NPC1RAB9AL3MBTL1TYK2TSHR | |
| SCHEMBL4366803 | 0.80 | NPC1 (0.36) | KCNA3KCNA5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6985552 | 0.79 | GAA (0.35) | NPC1RAB9ASMN1; SMN2MAPK1GSK3A | |
| SCHEMBL6988211 | 0.78 | POLB (0.40) | NPC1RAB9AMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL6989487 | 0.74 | ALDH1A1 (0.49) | RAB9ASMN1; SMN2ALDH1A1KMT2ATSHR | |
| SCHEMBL6991687 | 0.71 | KMT2A (0.42) | NPC1RAB9ASMN1; SMN2MAPK1USP2 | |
| SCHEMBL6990458 | 0.70 | CSF1R (0.44) | NPC1RAB9AALDH1A1KMT2ATSHR | |
| SCHEMBL6988050 | 0.70 | ALPL (0.43) | RAB9ASMN1; SMN2MAPK1L3MBTL1USP2 | |
| SCHEMBL6986333 | 0.69 | MEN1 (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |