Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.58 |
| ▸ | RELA | Q04206 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.55 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10474248 | 0.84 | PSMB8 (0.57) | SMN1; SMN2NPC1RAB9APKMNFKB1 | |
| SCHEMBL28498703 | 0.81 | PTGS2 (0.57) | SMN1; SMN2NPC1RAB9APKMNFKB1 | |
| SCHEMBL8799536 | 0.80 | CA1 (0.70) | SMN1; SMN2NFKB1NFKB2RELAALDH1A1 | |
| SCHEMBL8229512 | 0.80 | PSMB8 (0.64) | SMN1; SMN2NPC1RAB9APKMNFKB1 | |
| SCHEMBL6998874 | 0.77 | L3MBTL1 (0.71) | SMN1; SMN2NPC1RAB9APKMNFKB1 | |
| SCHEMBL210149 | 0.76 | SMN1; SMN2 (0.67) | SMN1; SMN2NPC1RAB9APKMNFKB1 | |
| SCHEMBL10474769 | 0.76 | PSMB8 (0.64) | SMN1; SMN2ALDH1A1L3MBTL1LMNAALOX15 | |
| SCHEMBL13407890 | 0.76 | ALDH1A1 (0.69) | SMN1; SMN2NPC1RAB9APKMNFKB1 | |
| SCHEMBL30147568 | 0.76 | ALDH1A1 (0.69) | SMN1; SMN2NPC1RAB9APKMNFKB1 | |
| SCHEMBL31452859 | 0.76 | TARS1 (0.61) | SMN1; SMN2NPC1RAB9AALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1335908-A2 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONISTS | ELI LILLY AND COMPANY (US) | 2003-08-20 | — | — | EP | disclosed |
| WO-2002038553-A2 | TRIAZOLE DERIVATIVES AND THEIR USE AS PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONISTS | ELI LILLY AND COMPANY (US) | 2002-05-16 | — | — | WO | disclosed |