Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 5/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983319 | 0.90 | ALDH1A1 (0.57) | CACNA1GMCHR1ALDH1A1 | |
| SCHEMBL5840932 | 0.89 | CACNA1G (0.60) | SIGMAR1CACNA1G | |
| Hydrochloric Acid SCHEMBL5841722 | 0.89 | ALDH1A1 (0.59) | CACNA1GMCHR1ALDH1A1 | |
| SCHEMBL5842521 | 0.86 | SIGMAR1 (0.57) | SIGMAR1CACNA1GMCHR1 | |
| SCHEMBL6978967 | 0.84 | LMNA (0.53) | SIGMAR1CACNA1GALDH1A1 | |
| Hydrochloric Acid SCHEMBL5842876 | 0.83 | KMT2A (0.55) | SIGMAR1CACNA1GALDH1A1 | |
| SCHEMBL6986958 | 0.83 | SMN1; SMN2 (0.54) | CACNA1GALDH1A1 | |
| SCHEMBL6987296 | 0.83 | ALDH1A1 (0.54) | SIGMAR1CACNA1GMCHR1ALDH1A1 | |
| SCHEMBL6981732 | 0.83 | MEN1 (0.54) | SIGMAR1ALDH1A1 | |
| SCHEMBL6986043 | 0.83 | SHMT2 (0.50) | CACNA1GALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |