Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | SLC40A1 | Q9NP59 | 10/20 | 0.54 |
| ▸ | G6PD | P11413 | 1/20 | 0.54 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.54 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.54 |
| ▸ | METAP2 | P50579 | 1/20 | 0.54 |
| ▸ | METAP1 | P53582 | 1/20 | 0.54 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.54 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.53 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985862 | 0.88 | ALDH1A1 (0.78) | LMNASMN1; SMN2ALDH1A1SLC40A1G6PD | |
| SCHEMBL2055443 | 0.85 | CYP3A4 (0.61) | LMNASMN1; SMN2ALDH1A1SLC40A1PTPN2 | |
| SCHEMBL27214308 | 0.84 | GLO1 (0.55) | LMNASMN1; SMN2ALDH1A1SLC40A1GLO1 | |
| SCHEMBL6979083 | 0.80 | SMN1; SMN2 (0.74) | LMNASMN1; SMN2ALDH1A1GLO1ATM | |
| SCHEMBL25920736 | 0.79 | GPR27 (0.73) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2614387 | 0.79 | SMN1; SMN2 (1.00) | LMNASMN1; SMN2ALDH1A1ATMMEN1 | |
| SCHEMBL6984395 | 0.79 | GLO1 (0.56) | ALDH1A1GLO1PTPN2PTPN1PTPN5 | |
| SCHEMBL18553742 | 0.78 | HTR6 (0.60) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL6981076 | 0.76 | ALDH1A1 (0.76) | LMNASMN1; SMN2ALDH1A1SLC40A1MEN1 | |
| SCHEMBL6982196 | 0.76 | ALDH1A1 (0.76) | LMNASMN1; SMN2ALDH1A1TDP1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991624-B1 | PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-11-19 | — | — | EP | disclosed |
| US-6300342-B1 | FOR THERAPY OR INHIBITING THROMBUS FORMATION; FOR THERAPY OF FIBRIN-DEPENDENT INFLAMMATORY CONDITION | BOEHRINGER INGELHEIM PHARM KG (DE) | 2001-10-09 | — | — | US | disclosed |
| EP-0991624-A1 | PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT | Boehringer Ingelheim Pharma KG (DE) | 2000-04-12 | — | — | EP | disclosed |
| WO-1999000371-A1 | PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-01-07 | — | — | WO | disclosed |