Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 13/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985955 | 0.89 | NAMPT (0.37) | MCHR1EPHX2DHODH | |
| SCHEMBL6987802 | 0.89 | KMT2A (0.41) | EPHX2 | |
| SCHEMBL6989326 | 0.87 | RAB9A (0.38) | TRPV1NR1H4 | |
| SCHEMBL6985875 | 0.86 | LMNA (0.40) | MCHR1 | |
| SCHEMBL6985259 | 0.84 | HDAC1 (0.40) | — | |
| SCHEMBL6987790 | 0.83 | TAS1R3 (0.38) | — | |
| SCHEMBL6986287 | 0.80 | CHRM4 (0.39) | — | |
| SCHEMBL6990430 | 0.78 | GCGR (0.41) | — | |
| SCHEMBL6749621 | 0.78 | CTSK (0.45) | — | |
| SCHEMBL6981853 | 0.76 | TRPV1 (0.42) | TRPV1EPHX2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362042-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057249-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |