Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.38 |
| ▸ | PLD2 | O14939 | 1/20 | 0.35 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985875 | 0.88 | LMNA (0.40) | RAB9ANPC1SMN1; SMN2GAATHRB | |
| SCHEMBL6989326 | 0.87 | RAB9A (0.38) | RAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL6985259 | 0.86 | HDAC1 (0.40) | RAB9ANPC1SMN1; SMN2NAMPTDRD2 | |
| SCHEMBL6985955 | 0.86 | NAMPT (0.37) | RAB9ANPC1NAMPT | |
| SCHEMBL6987802 | 0.84 | KMT2A (0.41) | RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6986218 | 0.83 | TRPV1 (0.40) | — | |
| SCHEMBL6986287 | 0.82 | CHRM4 (0.39) | RAB9ANPC1SMN1; SMN2DRD2DRD4 | |
| SCHEMBL6990430 | 0.81 | GCGR (0.41) | DRD2DRD3 | |
| SCHEMBL6752408 | 0.77 | TAS1R3 (0.53) | TAS1R3TAS1R1 | |
| SCHEMBL6988433 | 0.75 | TAS1R3 (0.35) | TAS1R3TAS1R1PLD2PLD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362042-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057249-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |