Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 2/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 12/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985875 | 0.83 | LMNA (0.40) | — | |
| SCHEMBL6989326 | 0.82 | RAB9A (0.38) | — | |
| SCHEMBL6985259 | 0.81 | HDAC1 (0.40) | DRD2DRD3 | |
| SCHEMBL6985955 | 0.81 | NAMPT (0.37) | GCGR | |
| SCHEMBL6987790 | 0.81 | TAS1R3 (0.38) | DRD2DRD3 | |
| SCHEMBL6751665 | 0.79 | KDM1A (0.42) | KDM1A | |
| SCHEMBL6987802 | 0.79 | KMT2A (0.41) | — | |
| SCHEMBL6986287 | 0.79 | CHRM4 (0.39) | DRD2HTR2A | |
| SCHEMBL6985501 | 0.78 | GCGR (0.41) | GCGRDGAT1KDM1AELOVL6 | |
| SCHEMBL6986218 | 0.78 | TRPV1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362042-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057249-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |