Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24700466 | 0.81 | LMNA (0.66) | LMNAHPGDFFAR1MAPK1ALDH1A1 | |
| SCHEMBL1720006 | 0.81 | LMNA (0.47) | LMNAHPGDFFAR1MAPK1ALDH1A1 | |
| SCHEMBL3263155 | 0.79 | LMNA (0.72) | LMNAHPGDFFAR1MAPK1ALDH1A1 | |
| SCHEMBL6994384 | 0.79 | ALDH1A1 (0.50) | LMNAHPGDMAPK1ALDH1A1MAPT | |
| SCHEMBL6992257 | 0.76 | MAPT (0.42) | LMNAHPGDMAPK1ALDH1A1MAPT | |
| SCHEMBL6989319 | 0.75 | ALDH1A1 (0.35) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3906094 | 0.75 | MAPK1 (0.62) | LMNAHPGDFFAR1MAPK1ALDH1A1 | |
| SCHEMBL23137230 | 0.74 | LMNA (0.66) | LMNAHPGDFFAR1MAPK1ALDH1A1 | |
| SCHEMBL6990452 | 0.74 | ALDH1A1 (0.49) | LMNAHPGDMAPK1ALDH1A1MAPT | |
| SCHEMBL23137231 | 0.71 | LMNA (0.62) | LMNAHPGDFFAR1MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2452683-A2 | Methods for treating atherosclerosis | Amgen Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| EP-2037928-B1 | METHODS FOR TREATING ATHEROSCLEROSIS | AMGEN INC (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2008002591-A2 | METHODS FOR TREATING ATHEROSCLEROSIS | AMGEN INC (US) | 2008-01-03 | — | — | WO | disclosed |