Sugi Predict

Sugi Predict / Compounds / SCHEMBL698746

SCHEMBL698746

SCHEMBL698746

Cc1cccc([C@H](C)c2nccn2C(=O)OCc2ccc(Cl)cc2F)c1C

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ PTGER1 P34995 4/20 0.37
▸ CYP2C19 P33261 3/20 0.37
▸ CYP1A2 P05177 2/20 0.37
▸ CYP2C9 P11712 2/20 0.37
▸ TBXA2R P21731 2/20 0.37
▸ PTGS1 P23219 2/20 0.37
▸ PTGER3 P43115 2/20 0.37
▸ PTGER2 P43116 2/20 0.37
▸ FFAR1 O14842 1/20 0.37
▸ HPD P32754 2/20 0.36
▸ KDM5A P29375 1/20 0.35
▸ KDM5B Q9UGL1 1/20 0.35
▸ GPR52 Q9Y2T5 1/20 0.34
▸ KCNH2 Q12809 1/20 0.34
▸ CYP2D6 P10635 1/20 0.34
▸ TSHR P16473 1/20 0.34
▸ HIF1A Q16665 1/20 0.34
▸ PTGDR2 Q9Y5Y4 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL697431 0.91 MAPK14 (0.39) PTGER1FFAR1KDM5AKDM5B
SCHEMBL696642 0.89 FPR2 (0.37) PTGER1HPD
SCHEMBL3533877 0.89 SCN5A (0.40) CYP2C19CYP1A2CYP2C9FFAR1CYP2D6
SCHEMBL703229 0.88 P2RX7 (0.32) CYP2C19CYP1A2CYP2C9FFAR1KCNH2
SCHEMBL698235 0.88 LMNA (0.32) FFAR1
SCHEMBL702153 0.88 GRIN2B (0.39) TSHR
SCHEMBL700359 0.87 L3MBTL1 (0.45) PTGER1CYP2C19CYP1A2CYP2C9
SCHEMBL698596 0.87 MMP2 (0.38) PTGER1FFAR1PTGDR2
SCHEMBL697262 0.87 LMNA (0.32) CYP2C19CYP1A2FFAR1
SCHEMBL698049 0.86 ALDH1A1 (0.39) FFAR1PTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2423199-A1 Substituted imidazoles and their use as pesticides Pfizer Limited (GB) 2012-02-29 — — EP disclosed
US-7825149-B2 Substituted imidazoles PFIZER LIMITED (GB) 2010-11-02 — — US disclosed
US-20090312326-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2009-12-17 — — US disclosed
US-7592362-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-09-22 — — US disclosed
US-7547718-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-06-16 — — US disclosed
US-7544706-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-06-09 — — US disclosed
US-20080125473-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2008-05-29 — — US disclosed
US-20080119536-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2008-05-22 — — US disclosed
US-20070167506-A1 SUBSTITUTED IMIDAZOLES PFIZER INC. (US) 2007-07-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080125473-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 PTGER1 3502/4885CYP2C19 16/4885CYP1A2 12/4885
US-20090312326-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 PTGER1 3502/4885CYP2C19 16/4885CYP1A2 12/4885
US-20070167506-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 PTGER1 3502/4885CYP2C19 16/4885CYP1A2 12/4885
US-20080119536-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 PTGER1 3502/4885CYP2C19 16/4885CYP1A2 12/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.