Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.50 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | DDO | Q99489 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990951 | 0.84 | DAO (0.49) | DAODDOCNR1 | |
| SCHEMBL6993972 | 0.81 | DAO (0.44) | DAODDOCNR1 | |
| SCHEMBL6988904 | 0.76 | CNR1 (0.58) | PTGS2PTGS1DAOCNR1 | |
| SCHEMBL6994150 | 0.76 | DAO (0.44) | PTGS2PTGS1DAODDO | |
| SCHEMBL7487224 | 0.75 | MAP2K4 (0.47) | DAODDO | |
| SCHEMBL7935589 | 0.74 | PTGS2 (0.56) | PTGS2PTGS1 | |
| SCHEMBL6943878 | 0.73 | DAO (0.40) | TDO2DAODDOCNR1 | |
| SCHEMBL6992345 | 0.73 | SIGMAR1 (0.46) | DAODDOCNR1 | |
| SCHEMBL28197849 | 0.72 | RORC (0.44) | PTGS2PTGS1 | |
| SCHEMBL549051 | 0.71 | DAO (0.47) | DAODDO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322646-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002008225-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |