Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.38 |
| ▸ | RHEB | Q15382 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 2/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989136 | 0.83 | DAO (0.49) | DRD4SIGMAR1DRD1KDM4CRHEB | |
| SCHEMBL6992345 | 0.78 | SIGMAR1 (0.46) | DRD4SIGMAR1DRD1RHEBDAO | |
| SCHEMBL6992353 | 0.78 | LOXL2 (0.49) | KDM4CKDM5AKDM5BKIF11 | |
| SCHEMBL24380299 | 0.75 | KIF11 (0.45) | METAP2NR3C1PGRNR3C2NPBWR1 | |
| SCHEMBL6619148 | 0.75 | PCSK9 (0.57) | DAO | |
| SCHEMBL23932536 | 0.75 | METAP2 (0.45) | METAP2NR3C1PGRNR3C2NPBWR1 | |
| SCHEMBL6989977 | 0.74 | CYP1A2 (0.50) | KCNH2 | |
| SCHEMBL28478744 | 0.74 | NR3C1 (0.35) | DRD4SIGMAR1DRD1METAP2NR3C1 | |
| SCHEMBL21866146 | 0.74 | RORC (0.42) | DRD4SIGMAR1DRD1NR3C1PGR | |
| SCHEMBL17027129 | 0.74 | F2 (0.55) | KDM4CKDM5AKDM5BNR3C1NPBWR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244652-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY | Cell Therapeutics Europe S.R.L. (IT) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047916-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2001-07-05 | — | — | WO | disclosed |