Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994384 | 0.81 | ALDH1A1 (0.50) | TSHRALDH1A1RAB9AHPGDMAPT | |
| SCHEMBL1719852 | 0.80 | TSHR (0.35) | TSHRALDH1A1RAB9AKDM4EHPGD | |
| SCHEMBL6992257 | 0.78 | MAPT (0.42) | ALDH1A1RAB9AHPGDMAPTHTT | |
| SCHEMBL6989319 | 0.77 | ALDH1A1 (0.35) | ALDH1A1RAB9AKDM4EMAPTNPC1 | |
| SCHEMBL6990452 | 0.76 | ALDH1A1 (0.49) | ALDH1A1RAB9AHPGDMAPTHTT | |
| SCHEMBL2358144 | 0.76 | MAPT (0.46) | TSHRALDH1A1RAB9AKDM4EHPGD | |
| SCHEMBL6987163 | 0.75 | MAPT (0.38) | MAPT | |
| SCHEMBL6987084 | 0.75 | LMNA (0.50) | TSHRALDH1A1RAB9AKDM4EHPGD | |
| SCHEMBL6991176 | 0.72 | ICAM1 (0.43) | ALDH1A1RAB9AMAPTNPC1TP53 | |
| SCHEMBL6988762 | 0.72 | MAPT (0.38) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2452683-A2 | Methods for treating atherosclerosis | Amgen Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| EP-2037928-B1 | METHODS FOR TREATING ATHEROSCLEROSIS | AMGEN INC (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2008002591-A2 | METHODS FOR TREATING ATHEROSCLEROSIS | AMGEN INC (US) | 2008-01-03 | — | — | WO | disclosed |