Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 5/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989453 | 0.84 | KMT2A (0.42) | PTGS2SMN1; SMN2HTTALDH1A1KMT2A | |
| SCHEMBL6986812 | 0.79 | ALDH1A1 (0.40) | PTGS2SMN1; SMN2HTTALDH1A1KMT2A | |
| SCHEMBL7369460 | 0.78 | ADORA2B (0.47) | PTGS2SMN1; SMN2HTTHSD17B10ALDH1A1 | |
| SCHEMBL6990503 | 0.76 | TSHR (0.39) | PTGS2SMN1; SMN2HTTALDH1A1KMT2A | |
| SCHEMBL6985903 | 0.75 | FGFR1 (0.37) | SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL6979697 | 0.73 | CYP1A2 (0.44) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL6987042 | 0.73 | PDE10A (0.37) | SMN1; SMN2ALDH1A1KMT2ATSHR | |
| SCHEMBL6987419 | 0.72 | ALDH1A1 (0.43) | SMN1; SMN2HTTALDH1A1TSHR | |
| SCHEMBL6987183 | 0.71 | TSHR (0.45) | SMN1; SMN2HTTALDH1A1TSHRNPSR1 | |
| SCHEMBL6987206 | 0.71 | PDE1A (0.36) | SMN1; SMN2HTTALDH1A1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313733-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018382-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-07 | — | — | WO | disclosed |