Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.43 |
| ▸ | PDE4A | P27815 | 3/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989453 | 0.78 | KMT2A (0.42) | LMNAATMSMN1; SMN2TSHRNPC1 | |
| SCHEMBL6986812 | 0.75 | ALDH1A1 (0.40) | LMNAATMSMN1; SMN2TSHRNPC1 | |
| SCHEMBL6990765 | 0.73 | PTGS2 (0.44) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL7370402 | 0.72 | CYP1A2 (0.51) | CYP1A2LMNAPDE3APOLBNTRK1 | |
| SCHEMBL6990503 | 0.71 | TSHR (0.39) | LMNAATMSMN1; SMN2TSHRMAPK1 | |
| SCHEMBL6983368 | 0.71 | LMNA (0.38) | CYP1A2LMNAATMPOLBGFER | |
| SCHEMBL17111090 | 0.70 | RAB9A (0.52) | CYP1A2LMNASMN1; SMN2GFERNTRK1 | |
| SCHEMBL6985903 | 0.69 | FGFR1 (0.37) | SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL6987042 | 0.69 | PDE10A (0.37) | SMN1; SMN2TSHRMAPK1ALDH1A1KMT2A | |
| SCHEMBL29364871 | 0.68 | CYP1A2 (0.58) | CYP1A2PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313733-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018382-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-07 | — | — | WO | disclosed |