Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6996395 | 0.81 | HTR1A (0.57) | SLC6A4HTR1ADRD2HTR2A | |
| SCHEMBL6994370 | 0.76 | DRD2 (0.40) | SLC6A4HTR1ADRD2HTR7ADRA1D | |
| SCHEMBL5957061 | 0.75 | MAPT (0.49) | SLC6A4HTR1ADRD2KMT2AHTR2A | |
| SCHEMBL6627997 | 0.71 | HTR1A (0.55) | SLC6A4HTR1AADRA1DCYP2D6 | |
| SCHEMBL6627993 | 0.71 | HTR1A (0.67) | SLC6A4HTR1ADRD2 | |
| SCHEMBL5957135 | 0.69 | DRD2 (0.51) | DRD2KMT2A | |
| SCHEMBL6961404 | 0.68 | CYP2D6 (0.48) | SLC6A4HTR1ADRD2HTR7HTR6 | |
| SCHEMBL5527597 | 0.67 | CYP2D6 (0.52) | SLC6A4ADRA1DKMT2ACYP2D6 | |
| SCHEMBL14463200 | 0.67 | OPRM1 (0.62) | SLC6A4HTR1ADRD2HTR7HTR6 | |
| SCHEMBL5957055 | 0.66 | ALDH1A1 (0.55) | SLC6A4HTR1ADRD2CYP2D6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0932609-B1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO 2,3-e]INDOL-8-ONE | WYETH CORP (US) | 2003-05-14 | — | — | EP | claimed |
| EP-0932609-A1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO 2,3-e]INDOL-8-ONE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-08-04 | — | — | EP | claimed |
| WO-1998016530-A1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO[2,3-e]INDOL-8-ONE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-04-23 | — | — | WO | claimed |
| EP-0932609-B1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO 2,3-e]INDOL-8-ONE | WYETH CORP (US) | 2003-05-14 | — | — | EP | disclosed |