Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 4/20 | 0.44 |
| ▸ | DDO | Q99489 | 2/20 | 0.44 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994150 | 0.91 | DAO (0.44) | DAODDOITKNR3C1PGR | |
| SCHEMBL6990951 | 0.90 | DAO (0.49) | DAODDONR3C1PGRNR3C2 | |
| SCHEMBL6993553 | 0.81 | PTGS2 (0.50) | DAODDOCNR1 | |
| SCHEMBL6995615 | 0.81 | LOXL2 (0.57) | DAONR3C1PGRNR3C2KDM4E | |
| SCHEMBL7502282 | 0.79 | PCSK9 (0.57) | LOXL2PCSK9CNR1 | |
| SCHEMBL7487224 | 0.78 | MAP2K4 (0.47) | DAODDONR3C1PGRNR3C2 | |
| SCHEMBL6992345 | 0.78 | SIGMAR1 (0.46) | DAODDOLOXL2PCSK9CNR1 | |
| SCHEMBL6943878 | 0.78 | DAO (0.40) | DAODDONPY5RIDO1CNR1 | |
| SCHEMBL4803301 | 0.77 | SRD5A2 (0.51) | DAODDOITKKDM4EMAPT | |
| SCHEMBL549051 | 0.76 | DAO (0.47) | DAODDOITKNR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322646-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002008225-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |