Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.44 |
| ▸ | DDO | Q99489 | 1/20 | 0.44 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.44 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6993972 | 0.91 | DAO (0.44) | DAODDOPCSK9ALKBH3NR3C1 | |
| SCHEMBL6995615 | 0.88 | LOXL2 (0.57) | DAOPCSK9ALKBH3NR3C1PGR | |
| SCHEMBL6990951 | 0.87 | DAO (0.49) | DAODDOPCSK9NR3C1PGR | |
| SCHEMBL6943878 | 0.81 | DAO (0.40) | DAODDONPY5RPOLBGAA | |
| SCHEMBL6992345 | 0.81 | SIGMAR1 (0.46) | DAODDOPCSK9LOXL2 | |
| SCHEMBL6994522 | 0.79 | LOXL2 (0.53) | PCSK9LOXL2 | |
| SCHEMBL6993553 | 0.76 | PTGS2 (0.50) | DAODDOPTGS1PTGS2 | |
| SCHEMBL7502282 | 0.76 | PCSK9 (0.57) | PCSK9LOXL2 | |
| Hydroxyamine SCHEMBL4796191 | 0.75 | NR4A2 (0.46) | DAODDOITKKDM4EALDH1A1 | |
| SCHEMBL10412904 | 0.74 | MAPT (0.64) | DAODDOPCSK9ITKKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322646-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002008225-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |