Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.37 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8208443 | 0.80 | SLC6A2 (0.48) | CHRNB2CHRNA4OPRM1OPRL1 | |
| SCHEMBL29814732 | 0.77 | POLB (0.35) | CHRNB2CHRNA4CHRNA3CHRNB4 | |
| SCHEMBL23089785 | 0.77 | POLB (0.35) | CHRNB2CHRNA4CHRNA3CHRNB4 | |
| SCHEMBL7230532 | 0.77 | CHRNB2 (0.44) | CHRNB2CHRNA4OPRM1OPRL1 | |
| SCHEMBL6996390 | 0.76 | OPRL1 (0.45) | OPRM1OPRL1 | |
| SCHEMBL8782082 | 0.75 | OPRM1 (0.44) | OPRM1OPRL1 | |
| SCHEMBL15341980 | 0.75 | CHRNB2 (0.45) | CHRNB2CHRNA4CHRNA3 | |
| SCHEMBL29239381 | 0.69 | ALOX5 (0.41) | — | |
| SCHEMBL751133 | 0.67 | SLC6A3 (0.58) | CHRNB2CHRNA4OPRM1CHRNA3CHRNB1 | |
| SCHEMBL989888 | 0.67 | SLC6A3 (0.58) | CHRNB2CHRNA4OPRM1CHRNA3CHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946553-B1 | 8-AZABICYCLO 3.2.1]OCTANE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INSECTICIDES | SYNGENTA LTD (GB) | 2003-01-29 | — | — | EP | disclosed |
| US-6174894-B1 | Bicyclic amine derivatives | ZENECA LIMITED (GB) | 2001-01-16 | — | — | US | disclosed |
| US-6093726-A | AN INSECTICIDES, ACARICIDES OR NEMATICIDES | ZENECA LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |