Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23089785 | 1.00 | POLB (0.35) | POLBDGAT1NPC1RAB9AALOX5 | |
| SCHEMBL29239381 | 0.82 | ALOX5 (0.41) | ALOX5 | |
| SCHEMBL31507973 | 0.78 | NOS3 (0.41) | ALOX5 | |
| SCHEMBL29660648 | 0.77 | CHRNB2 (0.31) | CHRNA3CHRNB2CHRNB4CHRNA4 | |
| SCHEMBL29108162 | 0.77 | CHRNB2 (0.31) | CHRNA3CHRNB2CHRNB4CHRNA4 | |
| SCHEMBL6992756 | 0.77 | CHRNB2 (0.45) | CHRNA3CHRNB2CHRNB4CHRNA4 | |
| SCHEMBL20489698 | 0.74 | P2RX7 (0.36) | DGAT1 | |
| SCHEMBL31292693 | 0.71 | ALDH1A1 (0.39) | NPC1RAB9A | |
| SCHEMBL835876 | 0.71 | ALDH1A1 (0.39) | NPC1RAB9A | |
| SCHEMBL3602093 | 0.71 | DRD2 (0.41) | POLBCHRNA3CHRNB2CHRNB4CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119874700-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2025-04-25 | — | — | CN | disclosed |
| CN-114945366-B | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2025-01-07 | — | — | CN | disclosed |
| CN-114945366-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2022-08-26 | — | — | CN | disclosed |