Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CFB | P00751 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24365232 | 0.85 | KDM4E (0.56) | KDM4EALDH1A1GAATSHRHTT | |
| SCHEMBL11488897 | 0.85 | KDM4E (0.56) | KDM4EALDH1A1GAATSHRHTT | |
| SCHEMBL22201130 | 0.80 | CHRNB2 (0.53) | KDM4EALDH1A1GAATSHRHTT | |
| SCHEMBL2172790 | 0.80 | CHRNB2 (0.53) | KDM4EALDH1A1GAATSHRHTT | |
| SCHEMBL9070276 | 0.79 | DRD2 (0.53) | KDM4EALDH1A1GAATSHRHTT | |
| SCHEMBL28100926 | 0.75 | ALDH1A1 (0.60) | KDM4EALDH1A1GAATSHRHTT | |
| SCHEMBL23064641 | 0.75 | DRD2 (0.54) | KDM4EALDH1A1GAATSHRHTT | |
| SCHEMBL2047049 | 0.74 | HTR1A (0.49) | KDM4EALDH1A1GAATSHRHTT | |
| SCHEMBL24697142 | 0.73 | GBA1 (0.49) | SIGMAR1 | |
| SCHEMBL28742821 | 0.72 | OPRM1 (0.56) | KDM4EALDH1A1DRD2CFB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351936-A1 | ARYL PIPERIDINE AND PIPERAZINE DERIVATIVES AS INDUCERS OF LDL-RECEPTOR EXPRESSION | GLAXO GROUP LIMITED (GB) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002055496-A1 | ARYL PIPERIDINE AND PIPERAZINE DERIVATIVES AS INDUCERS OF LDL-RECEPTOR EXPRESSION | GLAXO GROUP LIMITED (GB) | 2002-07-18 | — | — | WO | disclosed |