Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.48 |
| ▸ | HTR2A | P28223 | 8/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 3/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.48 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.48 |
| ▸ | DRD1 | P21728 | 2/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10845076 | 0.80 | ADRA2A (0.55) | DRD2HTR2AADRA1AADRA1DADRA1B | |
| SCHEMBL6991545 | 0.75 | DRD2 (0.49) | DRD2HTR2AADRA1AADRA1DSLC6A4 | |
| SCHEMBL6994156 | 0.75 | DRD2 (0.50) | DRD2HTR2AADRA1AADRA1DSLC6A4 | |
| SCHEMBL6994776 | 0.73 | SLC6A4 (0.46) | DRD2ADRA1AADRA1DSLC6A4ADRA1B | |
| SCHEMBL6991007 | 0.71 | HTR1A (0.70) | DRD2HTR2AADRA1AADRA1DADRA1B | |
| SCHEMBL6991016 | 0.71 | DRD2 (0.60) | DRD2HTR2AADRA1AADRA1DSLC6A4 | |
| Hydrochloric Acid SCHEMBL7099125 | 0.71 | KCNH2 (0.71) | DRD2HTR2AADRA1AKCNH2ADRA1D | |
| SCHEMBL8320229 | 0.70 | DRD2 (0.48) | DRD2HTR2AADRA1AADRA1DSLC6A4 | |
| SCHEMBL3026960 | 0.70 | DRD2 (0.42) | DRD2HTR2AADRA1AADRA1DSLC6A4 | |
| SCHEMBL13222379 | 0.70 | DRD2 (0.42) | DRD2HTR2AADRA1AKCNH2ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0932609-B1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO 2,3-e]INDOL-8-ONE | WYETH CORP (US) | 2003-05-14 | — | — | EP | claimed |
| EP-0932609-A1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO 2,3-e]INDOL-8-ONE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-08-04 | — | — | EP | claimed |
| WO-1998016530-A1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO[2,3-e]INDOL-8-ONE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-04-23 | — | — | WO | claimed |
| EP-0932609-B1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO 2,3-e]INDOL-8-ONE | WYETH CORP (US) | 2003-05-14 | — | — | EP | disclosed |