Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 11/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6993769 | 0.88 | CHEK2 (0.53) | DGAT1KCNH2ADORA2ACYP2C9DRD2 | |
| SCHEMBL4562113 | 0.87 | DGAT1 (0.52) | DGAT1KCNH2ADORA2ACYP2C9DRD2 | |
| SCHEMBL4561989 | 0.85 | DGAT1 (0.56) | DGAT1KCNH2ADORA2ACYP2C9CHEK2 | |
| SCHEMBL6992361 | 0.85 | DGAT1 (0.46) | DGAT1KCNH2ADORA2ACYP2C9DRD2 | |
| SCHEMBL1687841 | 0.85 | HTR3E (0.54) | DGAT1KCNH2ADORA2ACYP2C9NPC1 | |
| SCHEMBL4543375 | 0.85 | CHEK2 (0.59) | DGAT1KCNH2ADORA2ACYP2C9CHEK2 | |
| SCHEMBL4561861 | 0.84 | DGAT1 (0.65) | DGAT1KCNH2ADORA2ACYP2C9 | |
| SCHEMBL4560992 | 0.84 | DGAT1 (0.57) | DGAT1KCNH2ADORA2ACYP2C9CHEK2 | |
| SCHEMBL4543095 | 0.84 | DGAT1 (0.53) | DGAT1KCNH2ADORA2ACYP2C9CHEK2 | |
| SCHEMBL4562539 | 0.84 | DGAT1 (0.54) | DGAT1KCNH2ADORA2ACYP2C9CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064569-A1 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-05-18 | — | — | WO | disclosed |