Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL2882663 | 0.96 | HIF1A (0.55) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL14739784 | 0.96 | HIF1A (0.55) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL5946683 | 0.96 | HIF1A (0.55) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Ethylenediamine SCHEMBL1030825 | 0.91 | — | — | |
| Piperazine SCHEMBL3905644 | 0.88 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Pyrrolidine SCHEMBL2814299 | 0.80 | — | — | |
| Piperazine SCHEMBL9562685 | 0.80 | NFKB1 (0.54) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperidine SCHEMBL4128881 | 0.77 | ALDH1A1 (0.64) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL4260232 | 0.77 | HIF1A (0.43) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL22494138 | 0.77 | DNM1 (0.57) | HIF1AMAPTPDE4AKDRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773866-A4 | USE OF METAL COMPLEXES | BIO LAYER PTY LTD (AU) | 2009-04-01 | — | — | EP | disclosed |
| EP-1773866-A1 | USE OF METAL COMPLEXES | Bio-Layer Pty Limited (AU) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006002472-A1 | USE OF METAL COMPLEXES | BIO-LAYER PTY LTD (AU) | 2006-01-12 | — | — | WO | disclosed |