Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998482 | 0.93 | CDKN1A (0.44) | PTGS2PTGS1BRD4CDKN1A | |
| SCHEMBL6993952 | 0.84 | HSD11B1 (0.59) | HSD11B1BRD4 | |
| SCHEMBL6995905 | 0.83 | PTGS2 (0.46) | PTGS2PTGS1 | |
| SCHEMBL6992970 | 0.80 | BRD4 (0.56) | HSD11B1BRD4 | |
| SCHEMBL17283465 | 0.73 | PTGS2 (0.63) | PTGS2PTGS1 | |
| SCHEMBL403028 | 0.73 | PTGS2 (0.63) | PTGS2PTGS1 | |
| SCHEMBL8654013 | 0.73 | PTGS2 (0.62) | PTGS2PTGS1 | |
| SCHEMBL6991232 | 0.72 | BRD4 (0.57) | HSD11B1BRD4 | |
| SCHEMBL7567894 | 0.72 | PTGS2 (0.53) | PTGS2PTGS1 | |
| Hydrogen Sulfide SCHEMBL19086306 | 0.71 | PTGS2 (0.61) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921119-B1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-07-02 | — | — | EP | disclosed |
| US-6114360-A | Pyrrole compounds | ADIR ET COMPAGNIE (FR) | 2000-09-05 | — | — | US | disclosed |
| US-6063804-A | Pyrrole compounds | ADIR ET COMPAGNIE (FR) | 2000-05-16 | — | — | US | disclosed |
| EP-0921119-A1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-06-09 | — | — | EP | disclosed |