Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A12 | P48065 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995954 | 0.73 | L3MBTL1 (0.46) | SLC6A12HTR2AGRM2ALDH1A1LMNA | |
| SCHEMBL8112492 | 0.72 | HTR2B (0.48) | SLC6A12HTR2AGRM2DRD3MEN1 | |
| SCHEMBL8112494 | 0.72 | SIGMAR1 (0.49) | SLC6A12HTR2AGRM2DRD3ALDH1A1 | |
| SCHEMBL4185437 | 0.71 | DRD2 (0.63) | GRM2MEN1KMT2A | |
| SCHEMBL27537051 | 0.70 | SMN1; SMN2 (0.45) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL27597066 | 0.69 | CYP2C9 (0.50) | MEN1KMT2A | |
| SCHEMBL27615754 | 0.69 | NPSR1 (0.67) | ALDH1A1LMNAKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL18493200 | 0.68 | NFE2L2 (0.44) | ALDH1A1LMNAKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL11960577 | 0.67 | KDM4E (0.47) | ALDH1A1KDM4ESMN1; SMN2HSD11B1 | |
| SCHEMBL17537239 | 0.67 | KDM4E (0.47) | ALDH1A1LMNAKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015446-B1 | (4-PIPERIDINYL)-1H-2-BENZOPYRAN DERIVATIVES USEFUL AS ANTIPSYCHOTIC AGENTS | AVENTIS PHARMA INC (US) | 2003-04-02 | — | — | EP | disclosed |
| US-6004982-A | SIDE EFFECT REDUCTION; SCHIZOPHRENIA | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |