Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | PTPRA | P18433 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | AGER | Q15109 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8831554 | 0.75 | PTGS2 (0.42) | PTPRANAPRTL3MBTL1LMNAP4HTM | |
| SCHEMBL9373154 | 0.74 | SRC (0.41) | SRCLMNAKDM4ETDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL22775404 | 0.73 | PTGS2 (0.41) | PTPRANAPRTL3MBTL1LMNAP4HTM | |
| SCHEMBL2647026 | 0.72 | ALDH1A1 (0.50) | L3MBTL1ALDH1A1ALOX15TSHRNPSR1 | |
| SCHEMBL3767996 | 0.72 | SLC6A3 (0.52) | SRCPTPRANAPRTL3MBTL1LMNA | |
| SCHEMBL27940696 | 0.70 | SRC (0.40) | SRCPTPRANAPRTL3MBTL1LMNA | |
| SCHEMBL24327756 | 0.70 | KMT2A (0.35) | PTPRANAPRTL3MBTL1LMNAP4HTM | |
| SCHEMBL895966 | 0.70 | LMNA (0.40) | PTPRALMNAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8765939 | 0.70 | CES2 (0.34) | PTPRANAPRTL3MBTL1LMNAP4HTM | |
| SCHEMBL26940504 | 0.70 | KMT2A (0.35) | PTPRANAPRTL3MBTL1LMNAP4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915875-B1 | SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2003-04-09 | — | — | EP | disclosed |
| US-6255305-B1 | PSYCHOLOGICAL DISORDERS | MERCK SHARP & DOHME LIMITED (GB) | 2001-07-03 | — | — | US | disclosed |