Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995095 | 0.83 | SLC6A3 (0.45) | KCNH2 | |
| SCHEMBL6998084 | 0.76 | HTR2A (0.38) | ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL7001284 | 0.73 | LMNA (0.44) | ALDH1A1LMNAMAPTKMT2ADRD2 | |
| SCHEMBL7001738 | 0.65 | ALDH1A1 (0.36) | ALDH1A1LMNAMAPTKMT2APOLB | |
| SCHEMBL4239004 | 0.64 | RARB (0.41) | ALDH1A1MAPTKMT2A | |
| SCHEMBL6841616 | 0.63 | LMNA (0.53) | ALDH1A1LMNAMAPTKMT2AKDM4E | |
| SCHEMBL7769506 | 0.63 | MEN1 (0.43) | ALDH1A1LMNAMAPTKMT2AKDM4E | |
| SCHEMBL4674968 | 0.63 | DRD2 (0.53) | ALDH1A1LMNAMAPTKMT2ADRD2 | |
| SCHEMBL4671412 | 0.62 | MGLL (0.49) | LMNAMAPTKMT2AKDM4E | |
| SCHEMBL8967555 | 0.62 | KMT2A (0.56) | ALDH1A1LMNAMAPTKMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242080-A4 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | UNIV GEORGETOWN (US) | 2003-01-22 | — | — | EP | claimed |
| EP-1242080-A1 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | GEORGETOWN UNIVERSITY (US) | 2002-09-25 | — | — | EP | claimed |
| WO-2001022964-A1 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | GEORGETOWN UNIVERSITY (US) | 2001-04-05 | — | — | WO | claimed |
| EP-1242080-A4 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | UNIV GEORGETOWN (US) | 2003-01-22 | — | — | EP | disclosed |
| EP-1242080-A1 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | GEORGETOWN UNIVERSITY (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001022964-A1 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | GEORGETOWN UNIVERSITY (US) | 2001-04-05 | — | — | WO | disclosed |