Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4067013 | 0.79 | KMT2A (0.60) | MAPK1MAPTKMT2AMEN1NPC1 | |
| SCHEMBL7672845 | 0.78 | ALDH1A1 (0.53) | FLT3MAPTKMT2AMEN1NPC1 | |
| SCHEMBL7672533 | 0.76 | ALDH1A1 (0.56) | FLT3MAPTKMT2AMEN1NPC1 | |
| SCHEMBL7670272 | 0.72 | RAB9A (0.61) | MAPK1NPC1RAB9AHPGD | |
| SCHEMBL1930005 | 0.72 | EPHB4 (0.40) | MAPK1FLT3MAPTKMT2AMEN1 | |
| SCHEMBL16246364 | 0.71 | PTK2 (0.49) | FLT3MAPTKMT2AMEN1TP53 | |
| SCHEMBL7002815 | 0.71 | POLB (0.55) | MAPK1MAPTKMT2AMEN1TP53 | |
| SCHEMBL7000771 | 0.71 | KDM4A (0.45) | FLT3MAPTKMT2AMEN1NPC1 | |
| SCHEMBL7006525 | 0.71 | HSD17B10 (0.47) | MAPK1KMT2AMEN1NPC1TP53 | |
| SCHEMBL364343 | 0.70 | BCAT2 (0.56) | BCAT2MAPTALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294707-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-03-26 | — | — | EP | claimed |
| US-6414013-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-07-02 | — | — | US | claimed |
| WO-2001098290-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-27 | — | — | WO | claimed |