Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | IKBKB | O14920 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | XDH | P47989 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1854144 | 0.81 | ALDH1A1 (0.70) | KDRLMNAALDH1A1KMT2AMITF | |
| SCHEMBL17413465 | 0.81 | IKBKB (0.55) | IKBKBKMT2ASCN2ANOTUMIDO1 | |
| SCHEMBL1853364 | 0.78 | LMNA (0.56) | LMNAALDH1A1KMT2AMITFTP53 | |
| SCHEMBL18284795 | 0.76 | KDM4E (0.57) | IKBKBLMNAALDH1A1KMT2ASCN2A | |
| SCHEMBL330565 | 0.75 | ALDH1A1 (0.66) | LMNAALDH1A1KMT2AMITFTP53 | |
| SCHEMBL5068328 | 0.75 | CYP1A2 (0.47) | IKBKBSCN2ANOTUMIDO1 | |
| SCHEMBL6967479 | 0.75 | MKNK1 (0.66) | LMNAALDH1A1KMT2AMITFTP53 | |
| SCHEMBL6960706 | 0.75 | ALDH1A1 (0.66) | IKBKBLMNAALDH1A1KMT2AMITF | |
| SCHEMBL28572920 | 0.75 | SMN1; SMN2 (0.66) | LMNAALDH1A1KMT2AMITFTP53 | |
| SCHEMBL30512092 | 0.75 | SMN1; SMN2 (0.66) | LMNAALDH1A1KMT2AMITFTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |
| EP-0945438-B1 | PYRAZOLE DERIVATIVES | BANYU PHARMA CO LTD (JP) | 2003-03-05 | — | — | EP | disclosed |
| US-6057335-A | Pyrazole derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2000-05-02 | — | — | US | disclosed |
| EP-0945438-A1 | PYRAZOLE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1999-09-29 | — | — | EP | disclosed |