Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003912 | 0.85 | LTB4R2 (0.43) | ALDH1A1HPGDMAPTSMN1; SMN2KDM4E | |
| SCHEMBL5738353 | 0.73 | ALDH1A1 (0.42) | ALDH1A1HPGDMAPTKDM4EMEN1 | |
| SCHEMBL7006235 | 0.73 | ALDH1A1 (0.43) | ALDH1A1HPGDMAPTSMN1; SMN2KDM4E | |
| SCHEMBL7110249 | 0.72 | PPARG (0.53) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7004935 | 0.71 | MAPT (0.44) | ALDH1A1HPGDMAPTKDM4EGAA | |
| SCHEMBL2810771 | 0.70 | HTR6 (0.56) | ALDH1A1HPGDMAPTSMN1; SMN2KDM4E | |
| SCHEMBL7002629 | 0.69 | GABRA1 (0.44) | ALDH1A1HPGDMAPTSMN1; SMN2KDM4E | |
| SCHEMBL9023953 | 0.69 | HSD17B10 (0.49) | ALDH1A1HPGDMAPTSMN1; SMN2KDM4E | |
| SCHEMBL5738604 | 0.69 | MAOB (0.40) | ALDH1A1HPGDMAPTKDM4EGAA | |
| SCHEMBL7006743 | 0.68 | TUBB4A (0.44) | ALDH1A1HPGDMAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341761-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-$g(g) BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002030895-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-η BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-04-18 | — | — | WO | disclosed |