Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.42 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002758 | 0.89 | KMT2A (0.64) | ALDH1A1KMT2ALMNAMAPTMEN1 | |
| SCHEMBL6998079 | 0.83 | KMT2A (0.64) | ALDH1A1KMT2ALMNAMAPTMEN1 | |
| SCHEMBL9710832 | 0.81 | KMT2A (0.78) | ALDH1A1KMT2ALMNAMAPTMEN1 | |
| SCHEMBL11743879 | 0.81 | KMT2A (0.78) | ALDH1A1KMT2ALMNAMAPTMEN1 | |
| SCHEMBL6995927 | 0.73 | SLC6A3 (0.66) | ALDH1A1KMT2ALMNAMAPTMEN1 | |
| SCHEMBL27563251 | 0.72 | SIGMAR1 (0.68) | OPRM1OPRK1OPRD1HTR2AOPRL1 | |
| SCHEMBL8967064 | 0.69 | ALDH1A1 (1.00) | ALDH1A1KMT2ALMNAMAPTMEN1 | |
| SCHEMBL11745258 | 0.69 | KMT2A (0.77) | ALDH1A1KMT2ALMNAMAPTMEN1 | |
| SCHEMBL8967060 | 0.69 | ALDH1A1 (1.00) | ALDH1A1KMT2ALMNAMAPTMEN1 | |
| SCHEMBL8967059 | 0.69 | ALDH1A1 (1.00) | ALDH1A1KMT2ALMNAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242080-A4 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | UNIV GEORGETOWN (US) | 2003-01-22 | — | — | EP | claimed |
| EP-1242080-A1 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | GEORGETOWN UNIVERSITY (US) | 2002-09-25 | — | — | EP | claimed |
| WO-2001022964-A1 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | GEORGETOWN UNIVERSITY (US) | 2001-04-05 | — | — | WO | claimed |