SCHEMBL7004057

SCHEMBL7004057

Cc1cccc(Cc2nnc(C(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NS(C)(=O)=O)C(C)C)C(C)C)o2)c1

nearest known ligand 0.47

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CMA1 P23946 1/20 0.47
ELANE P08246 19/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31628587 0.86 ELANE (0.51) CMA1ELANE
SCHEMBL7004717 0.86 ELANE (0.51) CMA1ELANE
SCHEMBL7511605 0.75 ELANE (0.58) ELANE
SCHEMBL29427202 0.74 ELANE (0.49) CMA1ELANE
SCHEMBL32682555 0.72 ELANE (0.46) CMA1ELANE
SCHEMBL28743639 0.71 ELANE (0.48) ELANE
SCHEMBL13014738 0.71 CMA1 (0.48) CMA1ELANE
SCHEMBL7202085 0.69 ELANE (0.59) ELANE
SCHEMBL13814740 0.69 ELANE (0.53) CMA1ELANE
SCHEMBL5992790 0.69 CMA1 (0.44) CMA1ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030216324-A1 Airway mucus secretion inhibitors ONO PHARMACEUTICAL CO., LTD. (JP) 2003-11-20 US claimed
US-20030212115-A1 Remedies for inflammatory bowel diseases ONO PHARMACEUTICAL CO., LTD. (JP) 2003-11-13 US claimed
EP-1323420-A1 REMEDIES FOR INFLAMMATORY BOWEL DISEASES ONO PHARMACEUTICAL CO., LTD. (JP) 2003-07-02 EP claimed
EP-1323419-A1 AIRWAY MUCUS SECRETION INHIBITORS ONO PHARMACEUTICAL CO., LTD. (JP) 2003-07-02 EP claimed
US-20030216324-A1 Airway mucus secretion inhibitors ONO PHARMACEUTICAL CO., LTD. (JP) 2003-11-20 US disclosed
US-20030212115-A1 Remedies for inflammatory bowel diseases ONO PHARMACEUTICAL CO., LTD. (JP) 2003-11-13 US disclosed
EP-1323420-A1 REMEDIES FOR INFLAMMATORY BOWEL DISEASES ONO PHARMACEUTICAL CO., LTD. (JP) 2003-07-02 EP disclosed
EP-1323419-A1 AIRWAY MUCUS SECRETION INHIBITORS ONO PHARMACEUTICAL CO., LTD. (JP) 2003-07-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030212115-A1 Remedies for inflammatory bowel diseases NOS3, TPMT, NOS2 CMA1 1941/4885ELANE 588/4885
US-20030216324-A1 Airway mucus secretion inhibitors MUC1, CFTR, SERPINB1 CMA1 63/4885ELANE 19/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.