Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | HPGD | P15428 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.43 |
| ▸ | TUBB | P07437 | 3/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.43 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.43 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.43 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.43 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003117 | 0.85 | FBP1 (0.50) | ALDH1A1HPGDKDM4EMAPTTUBB4A | |
| SCHEMBL7006749 | 0.80 | TUBB4A (0.56) | ALDH1A1HPGDKDM4EMAPTTUBB4A | |
| SCHEMBL7002632 | 0.78 | KMT2A (0.55) | ALDH1A1HPGDKDM4EMAPTTUBB4A | |
| SCHEMBL7005939 | 0.76 | ALDH1A1 (0.54) | ALDH1A1HPGDKDM4EMAPTTUBB4A | |
| SCHEMBL7003917 | 0.75 | KMT2A (0.54) | ALDH1A1HPGDKDM4EMAPTTUBB4A | |
| SCHEMBL1653154 | 0.72 | ALDH1A1 (0.49) | ALDH1A1HPGDKDM4EMAPTTUBB4A | |
| SCHEMBL6014766 | 0.69 | KMT2A (0.61) | ALDH1A1HPGDKDM4EMAPTTUBB4A | |
| SCHEMBL8472591 | 0.69 | MEN1 (0.62) | ALDH1A1HPGDKDM4EMAPTTUBB4A | |
| SCHEMBL7616574 | 0.68 | KMT2A (0.52) | ALDH1A1HPGDKDM4EMAPTTUBB4A | |
| SCHEMBL8475171 | 0.67 | KDM4E (0.56) | ALDH1A1HPGDKDM4EMAPTTUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341761-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-$g(g) BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002030895-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-η BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-04-18 | — | — | WO | disclosed |