Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 6/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6843624 | 0.81 | RIPK1 (0.51) | PRMT5WDR77KDM4EGAAKMT2A | |
| SCHEMBL7721019 | 0.81 | DDAH1 (0.44) | PRMT5WDR77KDM4EGAAKMT2A | |
| SCHEMBL7002080 | 0.80 | KDM4E (0.48) | PRMT5WDR77KDM4EGAAKMT2A | |
| SCHEMBL1917771 | 0.79 | RIPK1 (0.44) | PRMT5WDR77KDM4EGAAKMT2A | |
| SCHEMBL937977 | 0.79 | PKM (0.48) | PRMT5WDR77KDM4EGAAKMT2A | |
| SCHEMBL1552358 | 0.77 | RNASEH1 (0.54) | KDM4EGAAKMT2ACYP1A2CYP3A4 | |
| SCHEMBL9197306 | 0.77 | RIPK1 (0.48) | KDM4EGAAKMT2AATMCYP1A2 | |
| SCHEMBL20594099 | 0.77 | MAPT (0.46) | PRMT5WDR77KDM4EGAAKMT2A | |
| SCHEMBL29894060 | 0.77 | CHRM1 (0.53) | KDM4EGAAKMT2AATMCYP1A2 | |
| SCHEMBL29261995 | 0.77 | CHRM1 (0.53) | KDM4EGAAKMT2AATMCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003106430-A1 | BENZIMIDAZOLE INHIBITORS OF POLY(ADP-RIBOSYL) POLYMERASE | PFIZER INC. (US) | 2003-12-24 | — | — | WO | disclosed |