Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | BRD1 | O95696 | 1/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002522 | 0.80 | NQO2 (0.42) | CYP19A1NQO2KDM4EALDH1A1PDE3B | |
| SCHEMBL7007859 | 0.77 | BRD4 (0.41) | HTR2AHTR2CCYP19A1NQO2HSD17B10 | |
| SCHEMBL7004254 | 0.73 | DAO (0.46) | HSD17B10KDM4EALDH1A1GAAHPGD | |
| SCHEMBL7003203 | 0.72 | MTNR1A (0.43) | HSD17B10ALDH1A1HTTMAPTMEN1 | |
| SCHEMBL7003133 | 0.71 | CA2 (0.44) | HTR2AHTR2CALDH1A1PDE3BPDE3A | |
| SCHEMBL7002931 | 0.71 | KDM4E (0.46) | HTR2AHTR2CHSD17B10KDM4EALDH1A1 | |
| SCHEMBL434941 | 0.70 | CYP19A1 (0.56) | HTR2AHTR2CCYP19A1NQO2HSD17B10 | |
| SCHEMBL7006877 | 0.70 | HTR3E (0.37) | HTR2AHTR2CHSD17B10KDM4EALDH1A1 | |
| SCHEMBL1092786 | 0.68 | CDK4 (0.45) | HTR2AHTR2CCYP19A1NQO2HSD17B10 | |
| SCHEMBL1156104 | 0.67 | MAPT (0.50) | CYP19A1NQO2KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200439-B1 | 1,2-DIHYDRO-1-OXO-PARAZINO(1,2-A) INDOLE DERIVATIVES | NOVUSPHARMA SPA (IT) | 2003-06-25 | — | — | EP | disclosed |