Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | PKLR | P30613 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.41 |
| ▸ | PDE8A | O60658 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012894 | 0.90 | SMN1; SMN2 (0.48) | PKMRAB9AHTTNPSR1MITF | |
| SCHEMBL7010649 | 0.82 | PKM (0.46) | PKMRAB9AHTTNPSR1MITF | |
| SCHEMBL7016038 | 0.82 | SMN1; SMN2 (0.43) | PKMRAB9AHTTNPSR1PKLR | |
| SCHEMBL7012827 | 0.82 | TSHR (0.46) | PKMRAB9AHTTNPSR1MITF | |
| SCHEMBL7015953 | 0.79 | SMN1; SMN2 (0.41) | PKMRAB9AHTTNPSR1MITF | |
| SCHEMBL7010543 | 0.78 | RAB9A (0.40) | PKMRAB9AHTTNPSR1MITF | |
| SCHEMBL7010653 | 0.75 | PKM (0.45) | PKMHTTNPSR1MITFPKLR | |
| SCHEMBL9239206 | 0.73 | MAPK14 (0.44) | PKMRAB9AHTTNPSR1MITF | |
| SCHEMBL9239707 | 0.73 | RAB9A (0.67) | PKMRAB9AHTTNPSR1MITF | |
| SCHEMBL7010994 | 0.72 | ALDH1A1 (0.41) | PKMRAB9AHTTMITFPKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |