Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | PKLR | P30613 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012894 | 0.85 | SMN1; SMN2 (0.48) | PKMPKLRTDP1HTTMAPT | |
| SCHEMBL7012844 | 0.82 | HDAC1 (0.47) | TDP1HTTSMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL7011568 | 0.81 | HPGD (0.44) | PKMTDP1HTTMAPTSMN1; SMN2 | |
| SCHEMBL7008568 | 0.81 | PKM (0.41) | PKMPKLRTDP1HTTMAPT | |
| SCHEMBL7016038 | 0.77 | SMN1; SMN2 (0.43) | PKMPKLRTDP1HTTMAPT | |
| SCHEMBL7012224 | 0.77 | HTT (0.43) | TDP1HTTMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7019117 | 0.77 | LMNA (0.43) | HTTSMN1; SMN2ALDH1A1LMNATSHR | |
| SCHEMBL7013283 | 0.77 | HTT (0.40) | TDP1HTTMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7020546 | 0.76 | MAPT (0.41) | HTTMAPTSMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL7012004 | 0.76 | LMNA (0.40) | HTTMAPTSMN1; SMN2ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |