Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | BPTF | Q12830 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019042 | 0.91 | KAT2B (0.46) | HTTSMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL7018161 | 0.91 | CCR2 (0.39) | HTTSMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL7015497 | 0.89 | MAPT (0.42) | SMN1; SMN2LMNAMAPTALDH1A1TP53 | |
| SCHEMBL7010725 | 0.88 | NPC1 (0.42) | HTTLMNAMAPTALDH1A1VNN1 | |
| SCHEMBL7020546 | 0.85 | MAPT (0.41) | HTTSMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL7008568 | 0.79 | PKM (0.41) | HTTSMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL7010653 | 0.77 | PKM (0.45) | HTTSMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL7012844 | 0.76 | HDAC1 (0.47) | HTTSMN1; SMN2LMNAALDH1A1TP53 | |
| SCHEMBL7015600 | 0.76 | MAPT (0.43) | LMNAMAPTTP53POLBMEN1 | |
| SCHEMBL7019092 | 0.75 | MAPT (0.41) | HTTSMN1; SMN2MAPTTP53HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |