Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | PKLR | P30613 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.38 |
| ▸ | PDE6D | O43924 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE6A | P16499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7010994 | 0.86 | ALDH1A1 (0.41) | PKMPKLRTDP1LMNAHTT | |
| SCHEMBL7012004 | 0.82 | LMNA (0.40) | LMNAHTTPTGDR2SMN1; SMN2GAA | |
| SCHEMBL7010653 | 0.81 | PKM (0.45) | PKMPKLRTDP1LMNAHTT | |
| SCHEMBL7020546 | 0.80 | MAPT (0.41) | LMNAHTTSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL7013283 | 0.79 | HTT (0.40) | TDP1LMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL7011568 | 0.79 | HPGD (0.44) | PKMTDP1LMNAHTTSMN1; SMN2 | |
| SCHEMBL7010649 | 0.77 | PKM (0.46) | PKMPKLRTDP1LMNAHTT | |
| SCHEMBL7012844 | 0.75 | HDAC1 (0.47) | TDP1LMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7019117 | 0.74 | LMNA (0.43) | LMNAHTTSMN1; SMN2ALDH1A1NR3C1 | |
| SCHEMBL7012224 | 0.72 | HTT (0.43) | TDP1LMNAHTTSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |