Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 6/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014703 | 0.78 | RAPGEF4 (0.40) | RAPGEF4 | |
| SCHEMBL7684228 | 0.70 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL10303879 | 0.65 | RAPGEF4 (0.64) | RAPGEF4 | |
| SCHEMBL7683348 | 0.63 | CRHR1 (0.41) | CRHR1RAPGEF4 | |
| SCHEMBL23365996 | 0.62 | NOS3 (0.42) | — | |
| SCHEMBL5844792 | 0.62 | CRHR1 (0.44) | CRHR1RAPGEF4 | |
| SCHEMBL5866965 | 0.61 | CRHR1 (0.40) | CRHR1RAPGEF4LCK | |
| SCHEMBL7013499 | 0.61 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL14360930 | 0.61 | CRHR1 (0.44) | CRHR1RAPGEF4 | |
| SCHEMBL21725470 | 0.61 | UHRF1 (0.43) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920429-B1 | SUBSTITUTED PYRIDO- OR PYRIMIDO-CONTAINING 6,6- OR 6,7-BICYCLIC DERIVATIVES | PFIZER (US) | 2003-02-19 | — | — | EP | disclosed |