Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | VEGFA | P15692 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016774 | 0.89 | KDM4E (0.50) | L3MBTL1CA1CA2KDM4EALDH1A1 | |
| SCHEMBL7014578 | 0.81 | KDM4E (0.50) | L3MBTL1CA1CA2HTTKDM4E | |
| SCHEMBL7015213 | 0.81 | HTR6 (0.35) | HTTKDM4EALDH1A1HPGDHTR6 | |
| SCHEMBL7016019 | 0.77 | L3MBTL1 (0.50) | L3MBTL1CA1CA2RAPGEF4HTT | |
| SCHEMBL22990705 | 0.67 | L3MBTL1 (0.59) | L3MBTL1CA1CA2RAPGEF4HTT | |
| SCHEMBL16382709 | 0.65 | CA1 (0.53) | L3MBTL1CA1CA2RAPGEF4HTT | |
| SCHEMBL27893073 | 0.65 | L3MBTL1 (0.53) | L3MBTL1CA1CA2RAPGEF4HTT | |
| SCHEMBL30405595 | 0.65 | L3MBTL1 (0.65) | L3MBTL1CA1CA2RAPGEF4HTT | |
| SCHEMBL14735577 | 0.65 | L3MBTL1 (0.65) | L3MBTL1CA1CA2RAPGEF4HTT | |
| SCHEMBL12900477 | 0.65 | MEN1 (0.45) | L3MBTL1CA1CA2RAPGEF4HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877022-B1 | Sulfonylpyrimidine derivatives with anticancer activity | RUDJER BOSKOVIC INST (HR) | 2003-04-16 | — | — | EP | claimed |
| EP-0877022-A1 | Synthesis of the sulfonylpyrimidine derivatives with anticancer activity | Herbos d.d. (HR) | 1998-11-11 | — | — | EP | claimed |
| EP-0877022-A1 | Synthesis of the sulfonylpyrimidine derivatives with anticancer activity | Herbos d.d. (HR) | 1998-11-11 | — | — | EP | disclosed |