Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | HTR1F | P30939 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAT2A | P31153 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013936 | 0.81 | L3MBTL1 (0.46) | HTR6ALDH1A1HTTKDM4EHPGD | |
| SCHEMBL7016369 | 0.73 | HTR6 (0.37) | HTR6KDM4ELMNAMEN1KMT2A | |
| SCHEMBL17194143 | 0.67 | SMN1; SMN2 (0.46) | KEAP1ALDH1A1HTTKDM4ELMNA | |
| SCHEMBL7013955 | 0.66 | NR3C1 (0.45) | SCN9AKEAP1HTR1DHTR1BHTR1F | |
| SCHEMBL28431665 | 0.63 | L3MBTL1 (0.36) | KEAP1TGFBR1ALDH1A1HTTKDM4E | |
| SCHEMBL12017942 | 0.63 | ALDH1A1 (0.64) | GLO1ALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL9806949 | 0.62 | MAPT (0.43) | HPGDSMN1; SMN2KMT2A | |
| SCHEMBL20571528 | 0.62 | KEAP1 (0.37) | KEAP1ALDH1A1HTTKDM4ELMNA | |
| SCHEMBL2912664 | 0.62 | ALDH1A1 (0.50) | SCN9AKEAP1GLO1ALDH1A1HTT | |
| SCHEMBL1333471 | 0.62 | SCN9A (0.46) | SCN9AKEAP1GLO1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877022-B1 | Sulfonylpyrimidine derivatives with anticancer activity | RUDJER BOSKOVIC INST (HR) | 2003-04-16 | — | — | EP | claimed |
| EP-0877022-A1 | Synthesis of the sulfonylpyrimidine derivatives with anticancer activity | Herbos d.d. (HR) | 1998-11-11 | — | — | EP | claimed |
| EP-0877022-A1 | Synthesis of the sulfonylpyrimidine derivatives with anticancer activity | Herbos d.d. (HR) | 1998-11-11 | — | — | EP | disclosed |