Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014578 | 0.89 | KDM4E (0.50) | KDM4EHSD11B1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL7013936 | 0.89 | L3MBTL1 (0.46) | KDM4EHSD11B1L3MBTL1ALDH1A1BRD4 | |
| SCHEMBL7016019 | 0.77 | L3MBTL1 (0.50) | L3MBTL1ALDH1A1LMNAGAAPKM | |
| SCHEMBL7018583 | 0.71 | KDM4E (0.55) | KDM4EHSD11B1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL29506329 | 0.70 | HSD11B1 (0.91) | KDM4EHSD11B1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL3486583 | 0.70 | HSD11B1 (0.91) | KDM4EHSD11B1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL32667896 | 0.69 | SMN1; SMN2 (0.46) | KDM4EL3MBTL1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL7015213 | 0.68 | HTR6 (0.35) | KDM4EALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL3925050 | 0.68 | HSD11B1 (0.67) | KDM4EHSD11B1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL3146296 | 0.68 | KDM4E (0.58) | KDM4EHSD11B1ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877022-B1 | Sulfonylpyrimidine derivatives with anticancer activity | RUDJER BOSKOVIC INST (HR) | 2003-04-16 | — | — | EP | claimed |
| EP-0877022-A1 | Synthesis of the sulfonylpyrimidine derivatives with anticancer activity | Herbos d.d. (HR) | 1998-11-11 | — | — | EP | claimed |
| EP-0877022-B1 | Sulfonylpyrimidine derivatives with anticancer activity | RUDJER BOSKOVIC INST (HR) | 2003-04-16 | — | — | EP | disclosed |
| EP-0877022-A1 | Synthesis of the sulfonylpyrimidine derivatives with anticancer activity | Herbos d.d. (HR) | 1998-11-11 | — | — | EP | disclosed |