Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.57 |
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.48 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | UBE2N | P61088 | 2/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016047 | 0.80 | SMN1; SMN2 (0.66) | L3MBTL1SMN1; SMN2RXFP1ADORA2BALDH1A1 | |
| SCHEMBL7015211 | 0.80 | SMN1; SMN2 (0.52) | L3MBTL1HTR7HTR6SMN1; SMN2RXFP1 | |
| SCHEMBL7015995 | 0.80 | MAPT (0.40) | L3MBTL1HTR7HTR6SMN1; SMN2ALDH1A1 | |
| SCHEMBL1810048 | 0.77 | HTR7 (0.84) | L3MBTL1HTR7HTR6SMN1; SMN2RXFP1 | |
| SCHEMBL683655 | 0.77 | HTR7 (0.77) | L3MBTL1HTR7HTR6SMN1; SMN2RXFP1 | |
| SCHEMBL29256880 | 0.76 | ADORA2B (0.74) | L3MBTL1SMN1; SMN2RXFP1ADORA2BALDH1A1 | |
| SCHEMBL7011108 | 0.75 | LMNA (0.84) | L3MBTL1SMN1; SMN2RXFP1ADORA2BALDH1A1 | |
| SCHEMBL7018070 | 0.75 | LMNA (0.68) | L3MBTL1SMN1; SMN2RXFP1ADORA2BALDH1A1 | |
| SCHEMBL7011204 | 0.75 | LMNA (0.68) | L3MBTL1SMN1; SMN2RXFP1ADORA2BALDH1A1 | |
| SCHEMBL1944405 | 0.74 | ADORA2B (1.00) | L3MBTL1SMN1; SMN2RXFP1ADORA2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| US-5753664-A | ANTITUMOR AGENTS, PYRIMIDONES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |