Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 7/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 7/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018485 | 0.88 | AGTR2 (0.50) | AGTR1AGTR2 | |
| SCHEMBL9571751 | 0.87 | TLR7 (0.45) | AGTR1AGTR2TLR7 | |
| SCHEMBL7025070 | 0.82 | ENPP2 (0.52) | AGTR1AGTR2TBXAS1 | |
| SCHEMBL8912409 | 0.81 | TLR7 (0.47) | AGTR1AGTR2TLR7 | |
| SCHEMBL8543697 | 0.76 | AGTR2 (0.70) | AGTR1AGTR2 | |
| SCHEMBL7023774 | 0.75 | ALDH1A1 (0.55) | — | |
| SCHEMBL9040398 | 0.74 | AGTR2 (0.56) | AGTR1AGTR2 | |
| SCHEMBL9571749 | 0.72 | AGTR2 (0.45) | AGTR1AGTR2TLR7 | |
| SCHEMBL9043313 | 0.72 | AGTR2 (0.56) | AGTR1AGTR2 | |
| Water SCHEMBL9041722 | 0.71 | AGTR2 (0.55) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533058-B1 | Imidazo-fused iso- and heterocycles as angiotensin II antagonists | HOECHST AG (DE) | 2003-08-20 | — | — | EP | disclosed |
| EP-0533058-A1 | Imidazo-fused iso- and heterocycles as angiotensin II antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-03-24 | — | — | EP | disclosed |