SCHEMBL7018485

SCHEMBL7018485

CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc2c(Cl)c(C(=O)O)sc2c1

nearest known ligand 0.62

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR2 P50052 4/20 0.50
AGTR1 P30556 3/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7018487 0.88 AGTR1 (0.46) AGTR2AGTR1
SCHEMBL8912409 0.87 TLR7 (0.47) AGTR2AGTR1
SCHEMBL7025070 0.84 ENPP2 (0.52) AGTR2AGTR1
SCHEMBL9571751 0.80 TLR7 (0.45) AGTR2AGTR1
SCHEMBL8543694 0.77 AGTR2 (0.80) AGTR2AGTR1
SCHEMBL7023774 0.76 ALDH1A1 (0.55)
SCHEMBL6170644 0.75 AGTR2 (0.53) AGTR2AGTR1
SCHEMBL7007312 0.74 AGTR2 (0.63) AGTR2AGTR1
SCHEMBL9422793 0.72 ALDH1A1 (0.55) AGTR2AGTR1
SCHEMBL7020231 0.72 AGTR2 (0.60) AGTR2AGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-5262742-A None JP disclosed
EP-0533058-B1 Imidazo-fused iso- and heterocycles as angiotensin II antagonists HOECHST AG (DE) 2003-08-20 EP disclosed
US-5635525-A DIAGNOSTICS HOECHST AKTIENGESELLSCHAFT (DE) 1997-06-03 US disclosed
US-5444068-A Imidazopyridine derivatives as angiotensin II receptor antagonists, pharmaceuticals, and treatment of hypertension therewith HOECHST AKTIENGESELLSCHAFT (DE) 1995-08-22 US disclosed
JP-H05262742-A IMIDAZO-FUSED ISO-AND HETEROCYCLE HOECHST AG 1993-10-12 JP disclosed
EP-0533058-A1 Imidazo-fused iso- and heterocycles as angiotensin II antagonists HOECHST AKTIENGESELLSCHAFT (DE) 1993-03-24 EP disclosed